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Issue 3, 2013
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The role of metal ions in amyloid formation: general principles from model peptides

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Abstract

The mechanistic understanding of peptide self-assembly mediated by metal ions into amyloids or other structures has gained a lot of interest, mainly due to their importance in several neurodegenerative diseases. The use of short, easy-to-handle peptides has contributed to a better knowledge of structures and mechanisms that are also relevant for the native and longer peptides involved in the neurodegenerative diseases. Here, we review the results obtained with such “model systems” with the aim to identify and discuss fundamental parameters determining the self-aggregation with a special focus on the role of metal ions in this process.

Graphical abstract: The role of metal ions in amyloid formation: general principles from model peptides

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Publication details

The article was received on 05 Nov 2012, accepted on 25 Jan 2013 and first published on 25 Jan 2013


Article type: Tutorial Review
DOI: 10.1039/C3MT20219D
Citation: Metallomics, 2013,5, 183-192
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    The role of metal ions in amyloid formation: general principles from model peptides

    B. Alies, C. Hureau and P. Faller, Metallomics, 2013, 5, 183
    DOI: 10.1039/C3MT20219D

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