A bioinspired hybrid silica–protein material with antimicrobial activity by iron uptake

Fernando Carmona; Daniela Mendoza; Alicia Megía-Fernández; Francisco Santoyo-Gonzalez; José M. Domínguez-Vera

doi:10.1039/C3MT20211A

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A bioinspired hybrid silica–protein material with antimicrobial activity by iron uptake†

Fernando Carmona,^ab Daniela Mendoza,^a Alicia Megía-Fernández,^bc Francisco Santoyo-Gonzalez^bc and José M. Domínguez-Vera*^ab

Author affiliations

* Corresponding authors

^a Departamento de Química Inorgánica, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain
E-mail: josema@ugr.es
Fax: +34 958 428526
Tel: +34 958248097

^b Instituto de Biotecnología. Universidad de Granada, Spain

^c Departamento de Química Orgánica, Facultad de Ciencias. Universidad de Granada, 18071 Granada, Spain

Abstract

A silica–protein hybrid material has been prepared by simultaneous covalent deposition of apoferritin and lactoferrin on functionalized silica. This material exhibits strong antibacterial activity against E. coli due to its high iron-uptake capacity.