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Issue 6, 2013
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The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials

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Abstract

Recently, there has been an emergence of significant interest in silver-based antimicrobials. Our goal was to develop a radioactive tracer for investigating the biological fate of such compounds. Purified 111Ag was incorporated into the methylated caffeine analogue, IC1 to yield the silver carbene complex designated as [111Ag]SCC1 and investigated in biodistribution studies.

Graphical abstract: The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials

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Supplementary files

Article information


Submitted
13 Mar 2013
Accepted
01 May 2013
First published
02 May 2013

Med. Chem. Commun., 2013,4, 1015-1017
Article type
Concise Article

The use of 111Ag as a tool for studying biological distribution of silver-based antimicrobials

T. A. Aweda, O. Ikotun, T. Mastren, C. L. Cannon, B. Wright, W. J. Youngs, C. Cutler, J. Guthrie and S. E. Lapi, Med. Chem. Commun., 2013, 4, 1015
DOI: 10.1039/C3MD00082F

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