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Issue 6, 2013
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Design and synthesis of β-amino alcohol based β-lactam–isatin chimeras and preliminary analysis of in vitro activity against the protozoal pathogen Trichomonas vaginalis

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Abstract

We have described the synthesis of β-amino alcohol based β-lactam–isatin chimeras along with their in vitro evaluation against T. vaginalis. SAR studies showed dependence of activity on concentration as well as substituent on N-1 of β-lactam and C-5 of isatin with preference for a chloro-substituent for good activity.

Graphical abstract: Design and synthesis of β-amino alcohol based β-lactam–isatin chimeras and preliminary analysis of in vitro activity against the protozoal pathogen Trichomonas vaginalis

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The article was received on 19 Feb 2013, accepted on 09 Apr 2013 and first published on 16 Apr 2013


Article type: Concise Article
DOI: 10.1039/C3MD00057E
Med. Chem. Commun., 2013,4, 1018-1024

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    Design and synthesis of β-amino alcohol based β-lactam–isatin chimeras and preliminary analysis of in vitro activity against the protozoal pathogen Trichomonas vaginalis

    Nisha, V. Mehra, M. Hopper, N. Patel, D. Hall, L. A. Wrischnik, K. M. Land and V. Kumar, Med. Chem. Commun., 2013, 4, 1018
    DOI: 10.1039/C3MD00057E

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