Issue 5, 2013
From the journal:

MedChemComm

Evaluation of two cyclic di-peptides as inhibitors of CCL2 induced chemotaxis†

Mahsa Saleki,a   Neil Colgin,b   John A. Kirby,a   Steven L. Cobbb  and  Simi Ali*a  

* Corresponding authors

a Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK
E-mail: Simi.Ali@newcastle.ac.uk
Tel: +44 (0)1912227158

b Department of Chemistry, Durham University, South Road, Durham, UK

Abstract

Monocyte chemoattractant protein (CCL2) plays a major role in the recruitment of monocytes during inflammation. In this study we analysed properties of synthetic CCL2 inhibitors in inhibiting CCL2 mediated monocyte migration. Using trans-endothelial chemotaxis assays compounds C1 and C5 were found to significantly reduce CCL2 mediated migration. Flow based adhesion assays showed reduction in adhesion to VCAM-1 in the presence of 10 nM CCL2 and 50 μM C5 (p < 0.05). Further studies with these compounds can aid in their development as anti-inflammatory therapies.

Graphical abstract: Evaluation of two cyclic di-peptides as inhibitors of CCL2 induced chemotaxis

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Article information

DOI
https://doi.org/10.1039/C3MD00043E
Article type
Concise Article
Submitted
08 Feb 2013
Accepted
31 Mar 2013
First published
02 Apr 2013

Med. Chem. Commun., 2013,4, 860-864

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Evaluation of two cyclic di-peptides as inhibitors of CCL2 induced chemotaxis

M. Saleki, N. Colgin, J. A. Kirby, S. L. Cobb and S. Ali, Med. Chem. Commun., 2013, 4, 860 DOI: 10.1039/C3MD00043E

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