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Issue 46, 2013
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Copper-catalyzed asymmetric 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones

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Abstract

A highly regioselective and enantioselective copper-catalyzed 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones was developed. The 1,4-addition products were obtained regioselectively in high yields with up to 98% ee.

Graphical abstract: Copper-catalyzed asymmetric 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones

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Article information


Submitted
22 Mar 2013
Accepted
21 Apr 2013
First published
23 Apr 2013

Chem. Commun., 2013,49, 5292-5294
Article type
Communication

Copper-catalyzed asymmetric 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones

Z. Ma, F. Xie, H. Yu, Y. Zhang, X. Wu and W. Zhang, Chem. Commun., 2013, 49, 5292
DOI: 10.1039/C3CC42088D

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