Issue 46, 2013
From the journal:

Chemical Communications

Copper-catalyzed asymmetric 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones†

Zhenni Ma,a   Fang Xie,*a   Han Yu,a   Yiren Zhang,a   Xiaoting Wua  and  Wanbin Zhang*a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
E-mail: wanbin@sjtu.edu.cn
Fax: +86-21-5474-3265
Tel: +86-21-5474-3265

Abstract

A highly regioselective and enantioselective copper-catalyzed 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones was developed. The 1,4-addition products were obtained regioselectively in high yields with up to 98% ee.

Graphical abstract: Copper-catalyzed asymmetric 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones

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Article information

DOI
https://doi.org/10.1039/C3CC42088D
Article type
Communication
Submitted
22 Mar 2013
Accepted
21 Apr 2013
First published
23 Apr 2013

Chem. Commun., 2013,49, 5292-5294

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Copper-catalyzed asymmetric 1,4-conjugate addition of Grignard reagents to linear α,β,γ,δ-unsaturated ketones

Z. Ma, F. Xie, H. Yu, Y. Zhang, X. Wu and W. Zhang, Chem. Commun., 2013, 49, 5292 DOI: 10.1039/C3CC42088D

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