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Issue 57, 2013
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N-Triethylene glycol (N-TEG) as a surrogate for the N-methyl group: application to Sansalvamide A peptide analogs

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Abstract

Here we studied the N-triethylene glycol (N-TEG) group as a surrogate for the N-Me group in Sansalvamide A peptide. The five N-TEG and N-Me analogs of this cyclic pentapeptide were synthesized, and their biological activity, lipophilicity and conformational features were compared.

Graphical abstract: N-Triethylene glycol (N-TEG) as a surrogate for the N-methyl group: application to Sansalvamide A peptide analogs

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Article information


Submitted
09 Mar 2013
Accepted
24 May 2013
First published
28 May 2013

Chem. Commun., 2013,49, 6430-6432
Article type
Communication

N-Triethylene glycol (N-TEG) as a surrogate for the N-methyl group: application to Sansalvamide A peptide analogs

A. I. Fernández-Llamazares, J. García, V. Soto-Cerrato, R. Pérez-Tomás, J. Spengler and F. Albericio, Chem. Commun., 2013, 49, 6430
DOI: 10.1039/C3CC41788C

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