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Issue 50, 2013
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Locked nucleic acid: tighter is different

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This viewpoint briefly reviews the impact of Locked Nucleic Acid (LNA) oligonucleotides, first described in a ChemComm paper in 1998. A number of unique applications in oligonucleotide biotechnology have been made possible by the high binding affinity and specificity of LNA, and these provide the main focus of the viewpoint.

Graphical abstract: Locked nucleic acid: tighter is different

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Publication details

The article was received on 15 Jan 2013, accepted on 10 May 2013 and first published on 16 May 2013

Article type: Viewpoint
DOI: 10.1039/C3CC40340H
Chem. Commun., 2013,49, 5618-5620

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    Locked nucleic acid: tighter is different

    J. K. Watts, Chem. Commun., 2013, 49, 5618
    DOI: 10.1039/C3CC40340H

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