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Issue 9, 2013
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1,2,3-Triazoles as versatile directing group for selective sp2 and sp3 C–H activation: cyclizationvs substitution

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Abstract

Selective cyclization and substitution was achieved with designated 1,2,3-triazole acid auxiliary groups under Pd catalyzed C–H activation conditions. Both sp2 and sp3 C–H bonds were effectively activated, giving the desired products in good yields. This result revealed the first successful example of exclusive substitution using 1,2,3-triazole ligands, while another triazole-containing directing group dominantly gave cyclization under identical conditions.

Graphical abstract: 1,2,3-Triazoles as versatile directing group for selective sp2 and sp3 C–H activation: cyclization vs substitution

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Article information


Submitted
03 May 2013
Accepted
02 Jul 2013
First published
02 Jul 2013

Chem. Sci., 2013,4, 3712-3716
Article type
Edge Article

1,2,3-Triazoles as versatile directing group for selective sp2 and sp3 C–H activation: cyclization vs substitution

X. Ye, Z. He, T. Ahmed, K. Weise, N. G. Akhmedov, J. L. Petersen and X. Shi, Chem. Sci., 2013, 4, 3712
DOI: 10.1039/C3SC51211H

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