Jump to main content
Jump to site search

Issue 40, 2013
Previous Article Next Article

Catalytic synthesis of enantiopure mixed diacylglycerols – synthesis of a major M. tuberculosis phospholipid and platelet activating factor

Author affiliations

Abstract

An efficient catalytic one-pot synthesis of TBDMS-protected diacylglycerols has been developed, starting from enantiopure glycidol. Subsequent migration-free deprotection leads to stereo- and regiochemically pure diacylglycerols. This novel strategy has been applied to the synthesis of a major Mycobacterium tuberculosis phospholipid, its desmethyl analogue, and platelet activating factor.

Graphical abstract: Catalytic synthesis of enantiopure mixed diacylglycerols – synthesis of a major M. tuberculosis phospholipid and platelet activating factor

Back to tab navigation

Supplementary files

Article information


Submitted
18 Jul 2013
Accepted
22 Aug 2013
First published
23 Aug 2013

Org. Biomol. Chem., 2013,11, 6919-6928
Article type
Paper

Catalytic synthesis of enantiopure mixed diacylglycerols – synthesis of a major M. tuberculosis phospholipid and platelet activating factor

P. Fodran and A. J. Minnaard, Org. Biomol. Chem., 2013, 11, 6919
DOI: 10.1039/C3OB41483C

Social activity

Search articles by author

Spotlight

Advertisements