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Issue 9, 2013
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Benzofuran and indole synthesis via Cu(i)-catalyzed coupling of N-tosylhydrazone and o-hydroxy or o-amino phenylacetylene

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Abstract

A general and practical method to synthesize 2-substituted benzofurans and indoles is described. This method employs easily accessible N-tosylhydrazones and o-hydroxy or o-amino phenylacetylenes as substrates. The reaction proceeds through a CuBr-catalyzed coupling–allenylation–cyclization sequence under ligand-free conditions.

Graphical abstract: Benzofuran and indole synthesis via Cu(i)-catalyzed coupling of N-tosylhydrazone and o-hydroxy or o-amino phenylacetylene

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Publication details

The article was received on 22 Sep 2012, accepted on 30 Oct 2012 and first published on 30 Oct 2012


Article type: Paper
DOI: 10.1039/C2OB26867A
Org. Biomol. Chem., 2013,11, 1490-1497

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    Benzofuran and indole synthesis via Cu(I)-catalyzed coupling of N-tosylhydrazone and o-hydroxy or o-amino phenylacetylene

    T. Xiao, X. Dong and L. Zhou, Org. Biomol. Chem., 2013, 11, 1490
    DOI: 10.1039/C2OB26867A

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