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Issue 6, 2013
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Ultrafast cell switching for recording cell surface transitions: new insights into epidermal growth factor receptor signalling

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Abstract

A pinched-flow deflection technology was developed for rapid single cell switching between biochemical microenvironments. Millisecond switching was used to stimulate and preserve epidermal growth factor receptor (EGFR) autophosphorylation transitions. Intramolecular phosphorylation initiates signal transduction, is silenced by phosphatase activity until EGFR dimerization enables intermolecular phosphorylation to initiate downstream signalling.

Graphical abstract: Ultrafast cell switching for recording cell surface transitions: new insights into epidermal growth factor receptor signalling

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Publication details

The article was received on 23 Nov 2012, accepted on 11 Jan 2013 and first published on 14 Jan 2013


Article type: Communication
DOI: 10.1039/C3LC41297K
Lab Chip, 2013,13, 1031-1034

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    Ultrafast cell switching for recording cell surface transitions: new insights into epidermal growth factor receptor signalling

    Y. Chiang and J. West, Lab Chip, 2013, 13, 1031
    DOI: 10.1039/C3LC41297K

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