Jump to main content
Jump to site search

Issue 7, 2013
Previous Article Next Article

Disaggregation of microparticle clusters by induced magnetic dipole–dipole repulsion near a surface

Author affiliations

Abstract

Ensembles of magnetic particles are known to align and aggregate into multi-particle clusters in an applied magnetic field, and the physical laws governing these processes are well described in literature. However, it has been elusive how to achieve the opposite process, i.e. the disaggregation of particle clusters in a magnetic field. We report a novel method to disaggregate clusters of superparamagnetic microparticles using time-dependent magnetic fields. The disaggregating field is designed to generate repulsive dipole–dipole forces between the particles and to stabilize the disaggregated particles on a physical surface. We demonstrate the disaggregation of large clusters of several tens of particles, within about one minute, using fields generated by a multipole electromagnet. After the disaggregation process the particles are uniformly distributed over the surface and ready for further lab-on-chip processing. Our results represent a novel methodology to disaggregate magnetic particle clusters and thereby improve the effectiveness and reproducibility of biological assays based on magnetic microparticles.

Graphical abstract: Disaggregation of microparticle clusters by induced magnetic dipole–dipole repulsion near a surface

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Nov 2012, accepted on 16 Jan 2013 and first published on 18 Jan 2013


Article type: Paper
DOI: 10.1039/C3LC41229F
Lab Chip, 2013,13, 1394-1401
  • Open access: Creative Commons BY license
  •   Request permissions

    Disaggregation of microparticle clusters by induced magnetic dipole–dipole repulsion near a surface

    Y. Gao, A. van Reenen, M. A. Hulsen, A. M. de Jong, M. W. J. Prins and J. M. J. den Toonder, Lab Chip, 2013, 13, 1394
    DOI: 10.1039/C3LC41229F

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements