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Issue 50, 2013
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Locked nucleic acid: tighter is different

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Abstract

This viewpoint briefly reviews the impact of Locked Nucleic Acid (LNA) oligonucleotides, first described in a ChemComm paper in 1998. A number of unique applications in oligonucleotide biotechnology have been made possible by the high binding affinity and specificity of LNA, and these provide the main focus of the viewpoint.

Graphical abstract: Locked nucleic acid: tighter is different

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Article information


Submitted
15 Jan 2013
Accepted
10 May 2013
First published
16 May 2013

Chem. Commun., 2013,49, 5618-5620
Article type
Viewpoint

Locked nucleic acid: tighter is different

J. K. Watts, Chem. Commun., 2013, 49, 5618
DOI: 10.1039/C3CC40340H

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