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Issue 46, 2013
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A bioreducible linear poly(β-amino ester) for siRNA delivery

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Abstract

Described here is the synthesis and characterization of a novel, bioreducible linear poly(β-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of siRNA using this polymer achieved near-complete knockdown of a fluorescent marker gene in primary human glioblastoma cells with no cytotoxicity.

Graphical abstract: A bioreducible linear poly(β-amino ester) for siRNA delivery

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Article information


Submitted
28 Jan 2013
Accepted
11 Apr 2013
First published
11 Apr 2013

Chem. Commun., 2013,49, 5319-5321
Article type
Communication

A bioreducible linear poly(β-amino ester) for siRNA delivery

K. L. Kozielski, S. Y. Tzeng and J. J. Green, Chem. Commun., 2013, 49, 5319
DOI: 10.1039/C3CC40718G

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