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Issue 6, 2013
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Racemic marinopyrrole B by total synthesis

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Abstract

The first synthesis of marinopyrrole B, which is highly active against methicillin-resistant Staphylococcus aureus, is described. The route involved constructing a pyrrole ring on the nitrogen of a 3-bromo-4,5-dichloropyrrole by N-alkylation with a special Michael acceptor having an allylic leaving group; the second pyrrole ring was then formed by a Paal–Knorr reaction.

Graphical abstract: Racemic marinopyrrole B by total synthesis

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Article information


Submitted
30 Sep 2012
Accepted
23 Oct 2012
First published
25 Oct 2012

Chem. Commun., 2013,49, 558-560
Article type
Communication

Racemic marinopyrrole B by total synthesis

P. Cheng, D. L. J. Clive, S. Fernandopulle and Z. Chen, Chem. Commun., 2013, 49, 558
DOI: 10.1039/C2CC37110C

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