Issue 19, 2013
From the journal:

Analyst

Detection of IP-10 protein marker in undiluted blood serum via an electrochemical E-DNA scaffold sensor†

Andrew J. Bonham,a   Nicole G. Paden,b   Francesco Riccic  and  Kevin W. Plaxco*b  

* Corresponding authors

a Department of Chemistry, Metropolitan State University of Denver, Denver, CO 80217, USA
E-mail: abonham@msudenver.edu
Fax: +1 303 556 5399
Tel: +1 303 556 3929

b Department of Chemistry & Biochemistry, University of California, Santa Barbara, CA 93117, USA
E-mail: kwp@chem.ucsb.edu
Fax: +1 805 893 4120
Tel: +1 805 893 5558

c University of Rome Tor Vergata, Rome, Italy
E-mail: francesco.ricci@uniroma2.it
Tel: +39 06 72594422

Abstract

We describe an electrochemical analog of fluorescence polarization that supports the quantitative measurement of a specific protein, the chemokine IP-10, directly in undiluted blood serum. The sensor is label-free, wash-free, and electronic, suggesting it could support point-of-care detection of diagnostic proteins in largely unprocessed clinical samples.

Graphical abstract: Detection of IP-10 protein marker in undiluted blood serum via an electrochemical E-DNA scaffold sensor

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Article information

DOI
https://doi.org/10.1039/C3AN01079A
Article type
Communication
Submitted
29 May 2013
Accepted
23 Jul 2013
First published
25 Jul 2013

Analyst, 2013,138, 5580-5583

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Detection of IP-10 protein marker in undiluted blood serum via an electrochemical E-DNA scaffold sensor

A. J. Bonham, N. G. Paden, F. Ricci and K. W. Plaxco, Analyst, 2013, 138, 5580 DOI: 10.1039/C3AN01079A

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