We discuss the formation, evolution, and stability of microfluidic flows involving two or more miscible fluids that have different viscosities. When two liquids that have widely different viscosities are injected into a rigid microfluidic device, their flow streams can naturally rearrange to form lubricated threads or stratified flows depending on the geometry and history of injection. An overview of two-fluid and three-fluid flow configurations in microchannels having square cross-sections is given for a variety of injection geometries. Miscible viscous fluid threads in confined microsystems can experience a range of viscous instabilities, such as folding and swirling. We show that microfluidics can be used to cause two or more instabilities to interact and co-evolve in diverging microchannels, thereby creating a variety of complex flow patterns.