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Issue 41, 2012
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Microfluidic systems for single DNA dynamics

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Abstract

Recent advances in microfluidics have enabled the molecular-level study of polymer dynamics using single DNA chains. Single polymer studies based on fluorescence microscopy allow for the direct observation of non-equilibrium polymer conformations and dynamical phenomena such as diffusion, relaxation, and molecular stretching pathways in flow. Microfluidic devices have enabled the precise control of model flow fields to study the non-equilibrium dynamics of soft materials, with device geometries including curved channels, cross slots, and microfabricated obstacles and structures. This review explores recent microfluidic systems that have advanced the study of single polymer dynamics, while identifying new directions in the field that will further elucidate the relationship between polymer microstructure and bulk rheological properties.

Graphical abstract: Microfluidic systems for single DNA dynamics

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Article information


Submitted
03 May 2012
Accepted
14 Jun 2012
First published
03 Jul 2012

Soft Matter, 2012,8, 10560-10572
Article type
Review Article

Microfluidic systems for single DNA dynamics

D. J. Mai, C. Brockman and C. M. Schroeder, Soft Matter, 2012, 8, 10560
DOI: 10.1039/C2SM26036K

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