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Issue 8, 2012
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A new approach for modular polymer–polymer conjugations via Heck coupling

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Heck coupling reactions are introduced as a modular, very efficient and highly orthogonal method for polymerpolymer conjugation. Several diblock and triblock copolymers (5200 Da ≤ Mn ≤ 17300 Da, 1.08 ≤ PDI ≤ 1.33) were prepared via Heck coupling reactions of acrylate-terminated and aryliodide-terminated polymers. The coupling reactions were performed using the so-called Jeffery's conditions, which allowed the use of equimolar amounts of reacting polymers and low reaction temperatures. Acrylated poly(ethylene glycol) monomethyl ether (PEG), poly(ε-caprolactone) (PCL) and polymers synthesized via head-to-tail selective acyclic diene metathesis (ADMET) polymerisation have been successfully conjugated with both a PEG and PCL containing an aryliodide moiety.

Graphical abstract: A new approach for modular polymer–polymer conjugations via Heck coupling

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Supplementary files

Article information

02 Apr 2012
15 May 2012
First published
16 May 2012

Chem. Sci., 2012,3, 2607-2615
Article type
Edge Article

A new approach for modular polymerpolymer conjugations via Heck coupling

M. Winkler, L. Montero de Espinosa, C. Barner-Kowollik and M. A. R. Meier, Chem. Sci., 2012, 3, 2607
DOI: 10.1039/C2SC20402A

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