Issue 8, 2012

A new approach for modular polymer–polymer conjugations via Heck coupling

Abstract

Heck coupling reactions are introduced as a modular, very efficient and highly orthogonal method for polymerpolymer conjugation. Several diblock and triblock copolymers (5200 Da ≤ Mn ≤ 17300 Da, 1.08 ≤ PDI ≤ 1.33) were prepared via Heck coupling reactions of acrylate-terminated and aryliodide-terminated polymers. The coupling reactions were performed using the so-called Jeffery's conditions, which allowed the use of equimolar amounts of reacting polymers and low reaction temperatures. Acrylated poly(ethylene glycol) monomethyl ether (PEG), poly(ε-caprolactone) (PCL) and polymers synthesized via head-to-tail selective acyclic diene metathesis (ADMET) polymerisation have been successfully conjugated with both a PEG and PCL containing an aryliodide moiety.

Graphical abstract: A new approach for modular polymer–polymer conjugations via Heck coupling

Supplementary files

Article information

Article type
Edge Article
Submitted
02 Apr 2012
Accepted
15 May 2012
First published
16 May 2012

Chem. Sci., 2012,3, 2607-2615

A new approach for modular polymerpolymer conjugations via Heck coupling

M. Winkler, L. Montero de Espinosa, C. Barner-Kowollik and M. A. R. Meier, Chem. Sci., 2012, 3, 2607 DOI: 10.1039/C2SC20402A

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