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Issue 38, 2012
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Quick regulation of mRNA functions by a few seconds of photoirradiation

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Abstract

3-Cyanovinylcarbazole nucleoside, which effectively photocrosslinks to the pyrimidine base in complementary RNA strands, was incorporated into antisense oligonucleotides, and we evaluated the photoreactivity and the sequence selectivity to mutated K-ras oligoRNAs, as well as the regulation of the function of K-ras mRNA. We demonstrated that the reverse transcription and the translation activity of K-ras mRNA were quickly suppressed by a few seconds of photoirradiation with the addition of the photoresponsive antisense ODN.

Graphical abstract: Quick regulation of mRNA functions by a few seconds of photoirradiation

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Publication details

The article was received on 09 May 2012, accepted on 07 Aug 2012 and first published on 08 Aug 2012


Article type: Paper
DOI: 10.1039/C2OB25883H
Org. Biomol. Chem., 2012,10, 7820-7825

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    Quick regulation of mRNA functions by a few seconds of photoirradiation

    A. Shigeno, T. Sakamoto, Y. Yoshimura and K. Fujimoto, Org. Biomol. Chem., 2012, 10, 7820
    DOI: 10.1039/C2OB25883H

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