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Issue 3, 2012

Organocatalytic asymmetric tandem condensation–intramolecular rearrangement–protonation: an approach to optically active α-amino thioester derivatives

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Abstract

An unprecedented and conceptually novel chiral Brønsted base/Brønsted acid catalytic method for the enantioselective synthesis of α-amino thioesters through a tandem condensation–intramolecular rearrangement–protonation has been developed which provides a number of important synthetic building blocks in good yield and with moderate to good enantioselectivities.

Graphical abstract: Organocatalytic asymmetric tandem condensation–intramolecular rearrangement–protonation: an approach to optically active α-amino thioester derivatives

Supplementary files

Article information


Submitted
22 Sep 2011
Accepted
21 Oct 2011
First published
25 Oct 2011

Org. Biomol. Chem., 2012,10, 490-494
Article type
Communication

Organocatalytic asymmetric tandem condensation–intramolecular rearrangement–protonation: an approach to optically active α-amino thioester derivatives

F. Capitta, A. Frongia, P. P. Piras, P. Pitzanti and F. Secci, Org. Biomol. Chem., 2012, 10, 490 DOI: 10.1039/C1OB06623D

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