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Issue 5, 2012
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Direct preparation of thiazoles, imidazoles, imidazopyridines and thiazolidines from alkenes

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Abstract

A range of heterocycles, namely thiazoles, imidazoles, imidazopyridines, thiazolidines and dimethoxyindoles, have been synthesised directly from alkenesvia a two-step ketoidoination/cyclisation protocol. The alkene starting materials are themselves readily accessible using many different and well-established approaches, and allow access to a variety of heterocycles with excellent yields and regioselectivity.

Graphical abstract: Direct preparation of thiazoles, imidazoles, imidazopyridines and thiazolidines from alkenes

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Article information


Submitted
16 Sep 2011
Accepted
11 Oct 2011
First published
12 Dec 2011

Org. Biomol. Chem., 2012,10, 1093-1101
Article type
Paper

Direct preparation of thiazoles, imidazoles, imidazopyridines and thiazolidines from alkenes

T. J. Donohoe, M. A. Kabeshov, A. H. Rathi and I. E. D. Smith, Org. Biomol. Chem., 2012, 10, 1093
DOI: 10.1039/C1OB06587D

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