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Issue 5, 2012
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Triazacyclophane (TAC)-scaffolded histidine and aspartic acid residues as mimics of non-heme metalloenzyme active sites

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Abstract

We describe the synthesis and coordination behaviour to copper(II) of two close structural triazacyclophane-based mimics of two often encountered aspartic acid and histidine containing metalloenzyme active sites. Coordination of these mimics to copper(I) and their reaction with molecular oxygen leads to the formation of dimeric bis(μ-hydroxo) dicopper(II) complexes.

Graphical abstract: Triazacyclophane (TAC)-scaffolded histidine and aspartic acid residues as mimics of non-heme metalloenzyme active sites

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Publication details

The article was received on 19 Aug 2011, accepted on 09 Nov 2011 and first published on 16 Nov 2011


Article type: Paper
DOI: 10.1039/C1OB06806G
Citation: Org. Biomol. Chem., 2012,10, 1088-1092

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    Triazacyclophane (TAC)-scaffolded histidine and aspartic acid residues as mimics of non-heme metalloenzyme active sites

    H. B. Albada, F. Soulimani, H. J. F. Jacobs, C. Versluis, B. M. Weckhuysen and R. M. J. Liskamp, Org. Biomol. Chem., 2012, 10, 1088
    DOI: 10.1039/C1OB06806G

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