The solid phase supported peptide synthesis of analogues of the lantibiotic lactocin S

Abstract

Four analogues of lactocin S, an antimicrobial lantibiotic peptide produced by Lactobacillus sakei L45, have been generated using solid-phase peptide chemistry. These analogues serve a dual purpose in enhancing the oxidative stability to atmospheric oxygen by removing susceptible sulfur atoms, while examining the structure–activity relationship of this biologically significant peptide.