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Issue 8, 2012
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The solid phase supported peptide synthesis of analogues of the lantibiotic lactocin S

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Abstract

Four analogues of lactocin S, an antimicrobial lantibiotic peptide produced by Lactobacillus sakei L45, have been generated using solid-phase peptide chemistry. These analogues serve a dual purpose in enhancing the oxidative stability to atmospheric oxygen by removing susceptible sulfur atoms, while examining the structure–activity relationship of this biologically significant peptide.

Graphical abstract: The solid phase supported peptide synthesis of analogues of the lantibiotic lactocin S

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Publication details

The article was received on 22 Jan 2012, accepted on 20 Feb 2012 and first published on 16 Mar 2012


Article type: Concise Article
DOI: 10.1039/C2MD20014G
Med. Chem. Commun., 2012,3, 971-975

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    The solid phase supported peptide synthesis of analogues of the lantibiotic lactocin S

    S. M. K. McKinnie, A. C. Ross, M. J. Little and J. C. Vederas, Med. Chem. Commun., 2012, 3, 971
    DOI: 10.1039/C2MD20014G

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