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Issue 8, 2012
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Stereochemistry of hydride transfer by group III alcohol dehydrogenases involved in phosphonate biosynthesis

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Abstract

Reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate is a common step in the biosynthesis of phosphonate natural products. The facial selectivity of hydride transfer from NADPH to phosphonoacetaldehyde was determined in this study in an effort to interrogate the biosynthetic pathway towards fosfomycin.

Graphical abstract: Stereochemistry of hydride transfer by group III alcohol dehydrogenases involved in phosphonate biosynthesis

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Publication details

The article was received on 19 Jan 2012, accepted on 13 Feb 2012 and first published on 29 Feb 2012


Article type: Concise Article
DOI: 10.1039/C2MD20009K
Med. Chem. Commun., 2012,3, 967-970

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    Stereochemistry of hydride transfer by group III alcohol dehydrogenases involved in phosphonate biosynthesis

    S. C. Peck, S. Y. Kim, B. S. Evans and W. A. van der Donk, Med. Chem. Commun., 2012, 3, 967
    DOI: 10.1039/C2MD20009K

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