Jump to main content
Jump to site search
Publishing
Advanced

Issue 8, 2012
Previous Article Next Article

Stereochemistry of hydride transfer by group III alcohol dehydrogenases involved in phosphonate biosynthesis†

Spencer C. Peck,ab   Seung Young Kim,b   Bradley S. Evansb  and  Wilfred A. van der Donk*ab  
Author affiliations

* Corresponding authors

a Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave., Urbana, IL, USA
E-mail: vddonk@illinois.edu
Fax: +1 217 244 8533
Tel: +1 217 244 5360

b Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL, USA

Abstract

Reduction of phosphonoacetaldehyde to 2-hydroxyethylphosphonate is a common step in the biosynthesis of phosphonate natural products. The facial selectivity of hydride transfer from NADPH to phosphonoacetaldehyde was determined in this study in an effort to interrogate the biosynthetic pathway towards fosfomycin.

Graphical abstract: Stereochemistry of hydride transfer by group III alcohol dehydrogenases involved in phosphonate biosynthesis

Back to tab navigation
Download options Please wait...

Publication details

The article was received on 19 Jan 2012, accepted on 13 Feb 2012 and first published on 29 Feb 2012


Article type: Concise Article
DOI: 10.1039/C2MD20009K
Med. Chem. Commun., 2012,3, 967-970

  •   Request permissions

    Stereochemistry of hydride transfer by group III alcohol dehydrogenases involved in phosphonate biosynthesis

    S. C. Peck, S. Y. Kim, B. S. Evans and W. A. van der Donk, Med. Chem. Commun., 2012, 3, 967
    DOI: 10.1039/C2MD20009K

    If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using Copyright Clearance Center. Go to our Instructions for using Copyright Clearance Center page for details.

    Authors contributing to RSC publications (journal articles, books or book chapters) do not need to formally request permission to reproduce material contained in this article provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      Reproduced from Ref. XX with permission from the Centre National de la Recherche Scientifique (CNRS) and The Royal Society of Chemistry.
    • For reproduction of material from PCCP:
      Reproduced from Ref. XX with permission from the PCCP Owner Societies.
    • For reproduction of material from PPS:
      Reproduced from Ref. XX with permission from the European Society for Photobiology, the European Photochemistry Association, and The Royal Society of Chemistry.
    • For reproduction of material from all other RSC journals and books:
      Reproduced from Ref. XX with permission from The Royal Society of Chemistry.

    If the material has been adapted instead of reproduced from the original RSC publication "Reproduced from" can be substituted with "Adapted from".

    In all cases the Ref. XX is the XXth reference in the list of references.

    If you are the author of this article you do not need to formally request permission to reproduce figures, diagrams etc. contained in this article in third party publications or in a thesis or dissertation provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Reproduced by permission of The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC
    • For reproduction of material from PCCP:
      [Original citation] - Reproduced by permission of the PCCP Owner Societies
    • For reproduction of material from PPS:
      [Original citation] - Reproduced by permission of The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC
    • For reproduction of material from all other RSC journals:
      [Original citation] - Reproduced by permission of The Royal Society of Chemistry

    If you are the author of this article you still need to obtain permission to reproduce the whole article in a third party publication with the exception of reproduction of the whole article in a thesis or dissertation.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements