Issue 45, 2012
From the journal:

Dalton Transactions

Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents†

Stephanie J. Lucas,a   Rianne M. Lord,a   Rachel L. Wilson,a   Roger M. Phillips,b   Visuvanathar Sridharana  and  Patrick C. McGowan*a  

* Corresponding authors

a School of Chemistry, University of Leeds, Woodhouse Lane, Leeds, UK
E-mail: P.C.McGowan@leeds.ac.uk
Fax: +44 (0)113436565
Tel: +44 (0)1133436404

b The Institute of Cancer Therapeutics, University of Bradford, West Yorkshire, UK
E-mail: R.M.Phillips@bradford.ac.uk
Fax: +44 (0)1274233234
Tel: +44 (0)1274235367

Abstract

Several Ru-arene and Ir–Cp* complexes have been prepared incorporating (N,N), (N,O) and (O,O) coordinating bidentate ligands and have been found to be active against both HT-29 and MCF-7 cell lines. By incorporating a biologically active ligand into a metal complex the anti-cancer activity is increased.

Graphical abstract: Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents

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Article information

DOI
https://doi.org/10.1039/C2DT32104A
Article type
Communication
Submitted
13 Aug 2012
Accepted
13 Sep 2012
First published
14 Sep 2012

Dalton Trans., 2012,41, 13800-13802

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Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents

S. J. Lucas, R. M. Lord, R. L. Wilson, R. M. Phillips, V. Sridharan and P. C. McGowan, Dalton Trans., 2012, 41, 13800 DOI: 10.1039/C2DT32104A

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