Issue 45, 2012
From the journal:

Dalton Transactions

Copper-64 labelling of triazacyclononane-triphosphinate chelators†

Jakub Šimeček,a   Hans-Jürgen Westera  and  Johannes Notni*a  

* Corresponding authors

a Pharmazeutische Radiochemie, Technische Universität München, Walther-Meißner-Str. 3, D-85748 Garching, Germany
E-mail: johannes.notni@tum.de

Abstract

The 1,4,7-triazacyclononane-1,4,7-tris(methylenephosphinic acid) chelators TRAP and NOPO are complexing copper-64 with similar efficiency as 1,4,7-triazacyclononane-triacetic acid (NOTA). The kinetic stability of Cu-64-labelled TRAP-peptides is sufficient for PET imaging at early time points (1–2 h post injection). For labelling of TRAP conjugates, Cu-64 can be recommended as an alternative to Ga-68 to achieve higher resolution of PET images.

Graphical abstract: Copper-64 labelling of triazacyclononane-triphosphinate chelators

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Article information

DOI
https://doi.org/10.1039/C2DT31880F
Article type
Communication
Submitted
16 Aug 2012
Accepted
27 Sep 2012
First published
08 Oct 2012

Dalton Trans., 2012,41, 13803-13806

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Copper-64 labelling of triazacyclononane-triphosphinate chelators

J. Šimeček, H. Wester and J. Notni, Dalton Trans., 2012, 41, 13803 DOI: 10.1039/C2DT31880F

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