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Issue 7, 2012
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Ionized form of acetaminophen with improved compaction properties

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Abstract

The most widely used antipyretic and analgesic drug, acetaminophen, has the long standing problem of extremely poor tableting properties and has been considered as non-ionizable. Here we report the synthesis of the first ionized solid-state structure, acetaminophen HCl monohydrate, and demonstrate its excellent tableting properties.

Graphical abstract: Ionized form of acetaminophen with improved compaction properties

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Article information


Submitted
26 Sep 2011
Accepted
04 Nov 2011
First published
09 Dec 2011

CrystEngComm, 2012,14, 2389-2390
Article type
Communication

Ionized form of acetaminophen with improved compaction properties

S. R. Perumalla, L. Shi and C. C. Sun, CrystEngComm, 2012, 14, 2389
DOI: 10.1039/C1CE06278F

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