Issue 97, 2012
From the journal:

Chemical Communications

One-step synthesis of novel glycosyltransferase inhibitors†

Andrew Evitt,a   Lauren M. Tedaldia  and  Gerd K. Wagner*ab  

* Corresponding authors

a Institute of Pharmaceutical Science, School of Biomedical Sciences, King's College London, London, UK

b Department of Chemistry, School of Biomedical Sciences, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London, UK
E-mail: gerd.wagner@kcl.ac.uk
Fax: +44 (0)20 7848 4045
Tel: +44 (0)20 7848 4747

Abstract

A one-step synthesis of two 5-CF3 UDP-sugars is reported. These non-natural sugar-nucleotides are micromolar inhibitors of two different galactosyltransferases.

Graphical abstract: One-step synthesis of novel glycosyltransferase inhibitors

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Article information

DOI
https://doi.org/10.1039/C2CC36798J
Article type
Communication
Submitted
18 Sep 2012
Accepted
23 Oct 2012
First published
05 Nov 2012

Chem. Commun., 2012,48, 11856-11858

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One-step synthesis of novel glycosyltransferase inhibitors

A. Evitt, L. M. Tedaldi and G. K. Wagner, Chem. Commun., 2012, 48, 11856 DOI: 10.1039/C2CC36798J

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