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Issue 77, 2012
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Triplex-directed covalent cross-linking of a DNA nanostructure

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Abstract

The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups to unique locations within these complexes.

Graphical abstract: Triplex-directed covalent cross-linking of a DNA nanostructure

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Publication details

The article was received on 26 Jul 2012, accepted on 09 Aug 2012 and first published on 10 Aug 2012


Article type: Communication
DOI: 10.1039/C2CC35407A
Chem. Commun., 2012,48, 9592-9594

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    Triplex-directed covalent cross-linking of a DNA nanostructure

    D. A. Rusling, I. S. Nandhakumar, T. Brown and K. R. Fox, Chem. Commun., 2012, 48, 9592
    DOI: 10.1039/C2CC35407A

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