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Issue 92, 2012
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An integrated fragment based screening approach for the discovery of small molecule modulators of the VWF–GPIbα interaction

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Abstract

An integrated approach comprising STD NMR screening, pharmacophore based analogue selection and a bioassay is presented for the discovery of a stabilizer of the clinically relevant VWF–GPIbα proteinprotein interaction.

Graphical abstract: An integrated fragment based screening approach for the discovery of small molecule modulators of the VWF–GPIbα interaction

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Article information


Submitted
21 Jul 2012
Accepted
01 Oct 2012
First published
16 Oct 2012

Chem. Commun., 2012,48, 11349-11351
Article type
Communication

An integrated fragment based screening approach for the discovery of small molecule modulators of the VWF–GPIbα interaction

R. A. Jose, A. Voet, K. Broos, A. J. Jakobi, G. Bruylants, B. Egle, K. Y. J. Zhang, M. De Maeyer, H. Deckmyn and W. M. De Borggraeve, Chem. Commun., 2012, 48, 11349
DOI: 10.1039/C2CC35269A

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