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Issue 92, 2012
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Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase

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Abstract

Diketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product.

Graphical abstract: Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase

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Supplementary files

Article information


Submitted
31 Aug 2012
Accepted
08 Oct 2012
First published
08 Oct 2012

Chem. Commun., 2012,48, 11352-11354
Article type
Communication

Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase

M. Lu, Y. Huang, M. A. White, X. Wu, N. Liu, X. Cheng and Y. Chen, Chem. Commun., 2012, 48, 11352
DOI: 10.1039/C2CC36334H

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