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Issue 31, 2012
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NHC-catalysed diastereoselective synthesis of multifunctionalised piperidinesvia cascade reaction of enals with azalactones

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Abstract

NHC-catalysed azalactone ring-opening and piperidine ring-closing cascade with α,β-unsaturated aldehydes (enals) in a one-pot operation is reported. The present reaction cascade offers a convenient method for a highly diastereoselective synthesis of multifunctionalised piperidines in excellent yields under mild conditions.

Graphical abstract: NHC-catalysed diastereoselective synthesis of multifunctionalised piperidines via cascade reaction of enals with azalactones

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Article information


Submitted
04 Jan 2012
Accepted
20 Feb 2012
First published
21 Feb 2012

Chem. Commun., 2012,48, 3766-3768
Article type
Communication

NHC-catalysed diastereoselective synthesis of multifunctionalised piperidines via cascade reaction of enals with azalactones

A. K. Singh, R. Chawla, A. Rai and L. D. S. Yadav, Chem. Commun., 2012, 48, 3766 DOI: 10.1039/C2CC00069E

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