Issue 31, 2012
From the journal:

Chemical Communications

Pd(ii)-catalyzed direct C5-arylation of azole-4-carboxylates through double C–H bond cleavage†

Ziyuan Li,a   Ling Ma,a   Jinyi Xu,a   Lingyi Kong,a   Xiaoming Wua  and  Hequan Yao*a  

* Corresponding authors

a State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, P. R. China
E-mail: hyao@cpu.edu.cn
Fax: +86 25-83301606
Tel: +86 25-83271042

Abstract

The first palladium-catalyzed direct C5-arylation of azole-4-carboxylates with simple unactivated arenes through double C–H bond cleavage is realized. This protocol provided a straightforward access to diverse 5-arylsubstituted azole-4-carboxylic derivatives with good functional group tolerance.

Graphical abstract: Pd(ii)-catalyzed direct C5-arylation of azole-4-carboxylates through double C–H bond cleavage

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Article information

DOI
https://doi.org/10.1039/C2CC00081D
Article type
Communication
Submitted
05 Jan 2012
Accepted
20 Feb 2012
First published
21 Feb 2012

Chem. Commun., 2012,48, 3763-3765

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Pd(II)-catalyzed direct C5-arylation of azole-4-carboxylates through double C–H bond cleavage

Z. Li, L. Ma, J. Xu, L. Kong, X. Wu and H. Yao, Chem. Commun., 2012, 48, 3763 DOI: 10.1039/C2CC00081D

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