Issue 3, 2012
From the journal:

Chemical Communications

Construction of a six-membered fused N-heterocyclic ring via a new 3-component reaction: synthesis of (pyrazolo)pyrimidines/pyridines†

P. Mahesh Kumar,ab   K. Siva Kumar,a   Pradeep Kumar Mohakhud,a   K. Mukkanti,b   R. Kapavarapu,c   Kishore V. L. Parsac  and  Manojit Pal*c  

* Corresponding authors

a Custom Pharmaceutical Services, Dr. Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad 500 049, India

b Chemistry Division, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad 500 049, India

c Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046, India
E-mail: manojitpal@rediffmail.com
Tel: +91 40 6657 1500

Abstract

A conceptually new three-component reaction was developed to construct a six-membered fused N-heterocyclic ring affording (pyrazolo)pyrimidines/pyridines as potential inhibitors of PDE4. The reaction is catalyzed by triflic acid in acetic acid in the presence of aerial oxygen.

Graphical abstract: Construction of a six-membered fused N-heterocyclic ring via a new 3-component reaction: synthesis of (pyrazolo)pyrimidines/pyridines

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Article information

DOI
https://doi.org/10.1039/C1CC16418J
Article type
Communication
Submitted
15 Oct 2011
Accepted
21 Oct 2011
First published
21 Oct 2011

Chem. Commun., 2012,48, 431-433

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Construction of a six-membered fused N-heterocyclic ring via a new 3-component reaction: synthesis of (pyrazolo)pyrimidines/pyridines

P. M. Kumar, K. S. Kumar, P. K. Mohakhud, K. Mukkanti, R. Kapavarapu, K. V. L. Parsa and M. Pal, Chem. Commun., 2012, 48, 431 DOI: 10.1039/C1CC16418J

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