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Issue 3, 2012
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Applications of p-hydroxyphenacyl (pHP) and coumarin-4-ylmethyl photoremovable protecting groups

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Abstract

Most applications of photoremovable protecting groups have used o-nitrobenzyl compounds and their (often commercially available) derivatives that, however, have several disadvantages. The focus of this review is on applications of the more recently developed title compounds, which are especially well suited for time-resolved biochemical and physiological investigations, because they release the caged substrates in high yield within a few nanoseconds or less. Together, these two chromophores cover the action spectrum for photorelease from >700 nm to 250 nm.

Graphical abstract: Applications of p-hydroxyphenacyl (pHP) and coumarin-4-ylmethyl photoremovable protecting groups

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Article information


Submitted
07 Dec 2011
Accepted
20 Jan 2012
First published
16 Feb 2012

Photochem. Photobiol. Sci., 2012,11, 472-488
Article type
Perspective

Applications of p-hydroxyphenacyl (pHP) and coumarin-4-ylmethyl photoremovable protecting groups

R. S. Givens, M. Rubina and J. Wirz, Photochem. Photobiol. Sci., 2012, 11, 472
DOI: 10.1039/C2PP05399C

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