Issue 45, 2012
From the journal:

Organic & Biomolecular Chemistry

Organocatalytic asymmetric biomimetic transamination of aromatic ketone to optically active amine†

Ying Xie,a   Hongjie Pan,a   Xiao Xiao,a   Songlei Lia  and  Yian Shi*ab  

* Corresponding authors

a Beijing National Laboratory of Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

b Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA
E-mail: yian@lamar.colostate.edu
Fax: +001-970-4911801
Tel: +001-970-4917424

Abstract

An asymmetric biomimetic transamination of aromatic ketones to optically active amines with o-HOPhCH2NH2 as amine source catalyzed by hydroquinine-derived chiral base is described. Up to 85% ee was obtained.

Graphical abstract: Organocatalytic asymmetric biomimetic transamination of aromatic ketone to optically active amine

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Article information

DOI
https://doi.org/10.1039/C2OB26782A
Article type
Communication
Submitted
11 Sep 2012
Accepted
04 Oct 2012
First published
05 Oct 2012

Org. Biomol. Chem., 2012,10, 8960-8962

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Organocatalytic asymmetric biomimetic transamination of aromatic ketone to optically active amine

Y. Xie, H. Pan, X. Xiao, S. Li and Y. Shi, Org. Biomol. Chem., 2012, 10, 8960 DOI: 10.1039/C2OB26782A

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