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Issue 32, 2012
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Ephedrine-based diselenide: a promiscuous catalyst suitable to mimic the enzyme glutathione peroxidase (GPx) and to promote enantioselective C–C coupling reactions

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Abstract

The ephedrine-based diselenide appears as a new promiscuous catalyst, able to generate optically active alcohols by addition of organozinc to aldehydes (up to 97% ee), and shows powerful GPx like activity, reducing H2O2 to water in only 16.33 min (eleven times faster than PhSeSePh).

Graphical abstract: Ephedrine-based diselenide: a promiscuous catalyst suitable to mimic the enzyme glutathione peroxidase (GPx) and to promote enantioselective C–C coupling reactions

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Publication details

The article was received on 12 Mar 2012, accepted on 27 Jun 2012 and first published on 28 Jun 2012


Article type: Paper
DOI: 10.1039/C2OB25539A
Org. Biomol. Chem., 2012,10, 6595-6599

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    Ephedrine-based diselenide: a promiscuous catalyst suitable to mimic the enzyme glutathione peroxidase (GPx) and to promote enantioselective C–C coupling reactions

    L. C. Soares, E. E. Alberto, R. S. Schwab, P. S. Taube, V. Nascimento, O. E. D. Rodrigues and A. L. Braga, Org. Biomol. Chem., 2012, 10, 6595
    DOI: 10.1039/C2OB25539A

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