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Issue 32, 2012
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Hexafluoroisopropanol: a powerful solvent for the hydrogenation of indole derivatives. Selective access to tetrahydroindoles or cis-fused octahydroindoles

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Abstract

Pd/C in HFIP was used to hydrogenate indole derivatives under relatively mild conditions, leading to potential synthetic intermediates of bioactive compounds. Depending on their substitution, tetrahydroindoles or octahydroindoles could selectively be obtained.

Graphical abstract: Hexafluoroisopropanol: a powerful solvent for the hydrogenation of indole derivatives. Selective access to tetrahydroindoles or cis-fused octahydroindoles

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Article information


Submitted
21 May 2012
Accepted
19 Jun 2012
First published
20 Jun 2012

Org. Biomol. Chem., 2012,10, 6587-6594
Article type
Paper

Hexafluoroisopropanol: a powerful solvent for the hydrogenation of indole derivatives. Selective access to tetrahydroindoles or cis-fused octahydroindoles

D. Clarisse, B. Fenet and F. Fache, Org. Biomol. Chem., 2012, 10, 6587
DOI: 10.1039/C2OB25980J

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