Issue 2, 2013

3,3-Dimethyl-1H-pyrrolo[3,2-g]quinolin-2(3H)-one derivatives as novel Raf kinase inhibitors

Abstract

A series of quinoline derivatives were designed and synthesized as tyrosine kinase inhibitors. Exploration of the structure–activity relationships resulted in compounds that are potent in vitro. In addition, compound 10f was found to be a potent and selective Raf kinase inhibitor.

Graphical abstract: 3,3-Dimethyl-1H-pyrrolo[3,2-g]quinolin-2(3H)-one derivatives as novel Raf kinase inhibitors

Article information

Article type
Concise Article
Submitted
13 Sep 2012
Accepted
13 Nov 2012
First published
10 Dec 2012

Med. Chem. Commun., 2013,4, 367-370

3,3-Dimethyl-1H-pyrrolo[3,2-g]quinolin-2(3H)-one derivatives as novel Raf kinase inhibitors

Y. Li, X. Shi, N. Xie, Y. Zhao and S. Li, Med. Chem. Commun., 2013, 4, 367 DOI: 10.1039/C2MD20275A

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