Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

There will be scheduled maintenance work beginning on Saturday 15th June 2019 at 8:30 am through to Sunday 16th June 2019 at 11:30 pm (BST).

During this time our website may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 2, 2012
Previous Article Next Article

Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors

Author affiliations

Abstract

The design and synthesis of a potent series of c-jun N-terminal kinase (JNK2) inhibitors is described. The development and optimization of the 2,4-diaminopyrimidines series was carried out from an earlier in-house kinase inhibitor program. Through the optimization of the scaffold 2, several cell potent compounds with good in vivo profiles were discovered.

Graphical abstract: Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Aug 2011, accepted on 03 Nov 2011 and first published on 01 Dec 2011


Article type: Concise Article
DOI: 10.1039/C1MD00219H
Med. Chem. Commun., 2012,3, 238-243

  •   Request permissions

    Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors

    X. Song, Y. He, M. Koenig, Y. Shin, R. Noel, W. Chen, Y. Y. Ling, D. Feurstein, L. Lin, C. H. Ruiz, M. D. Cameron, D. R. Duckett and T. M. Kamenecka, Med. Chem. Commun., 2012, 3, 238
    DOI: 10.1039/C1MD00219H

Search articles by author

Spotlight

Advertisements