Issue 2, 2012
From the journal:

MedChemComm

Simplified platensimycin analogues as antibacterial agents†

Dragan Krsta,a   Caron K. Ku,a   Ian T. Crosby,a   Ben Capuanoa  and  David T. Manallack*a  

* Corresponding authors

a Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Australia
E-mail: David.Manallack@monash.edu
Tel: +61 3 99039537

Abstract

A series of substituted 2-hydroxybenzoic acid derivatives were synthesized as simplified analogues of platensimycin. The final compounds were evaluated against the Gram-positive bacteria, methicillin-resistant Staphylococcus aureus. Analogues that possessed polycyclic groups directly attached to the substituted benzoic acid were able to demonstrate modest antimicrobial activity.

Graphical abstract: Simplified platensimycin analogues as antibacterial agents

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Article information

DOI
https://doi.org/10.1039/C2MD00252C
Article type
Concise Article
Submitted
06 Oct 2011
Accepted
25 Nov 2011
First published
30 Nov 2011

Med. Chem. Commun., 2012,3, 244-249

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Simplified platensimycin analogues as antibacterial agents

D. Krsta, C. K. Ku, I. T. Crosby, B. Capuano and D. T. Manallack, Med. Chem. Commun., 2012, 3, 244 DOI: 10.1039/C2MD00252C

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