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Issue 6, 2012
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Integrated three-dimensional filter separates nanoscale from microscale elements in a microfluidic chip

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Abstract

We report on the integration of a size-based three-dimensional filter, with micrometre-sized pores, in a commercial microfluidic chip. The filter is fabricated inside an already sealed microfluidic channel using the unique capabilities of two-photon polymerization. This direct-write technique enables integration of the filter by post-processing in a chip that has been fabricated by standard technologies. The filter is located at the intersection of two channels in order to control the amount of flow passing through the filter. Tests with a suspension of 3 μm polystyrene spheres in a Rhodamine 6G solution show that 100% of the spheres are stopped, while the fluorescent molecules are transmitted through the filter. We demonstrate operation up to a period of 25 minutes without any evidence of clogging. Preliminary validation of the device for plasma separation from whole blood is shown. Moreover, the filter can be cleaned and reused by reversing the flow.

Graphical abstract: Integrated three-dimensional filter separates nanoscale from microscale elements in a microfluidic chip

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Supplementary files

Article information


Submitted
16 Nov 2011
Accepted
03 Jan 2012
First published
05 Jan 2012

Lab Chip, 2012,12, 1135-1142
Article type
Paper

Integrated three-dimensional filter separates nanoscale from microscale elements in a microfluidic chip

L. Amato, Y. Gu, N. Bellini, S. M. Eaton, G. Cerullo and R. Osellame, Lab Chip, 2012, 12, 1135
DOI: 10.1039/C2LC21116E

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