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Issue 7, 2012
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High-sensitivity nanosensors for biomarker detection

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Abstract

High sensitivity nanosensors utilize optical, mechanical, electrical, and magnetic relaxation properties to push detection limits of biomarkers below previously possible concentrations. The unique properties of nanomaterials and nanotechnology are exploited to design biomarker diagnostics. High-sensitivity recognition is achieved by signal and target amplification along with thorough pre-processing of samples. In this tutorial review, we introduce the type of detection signals read by nanosensors to detect extremely small concentrations of biomarkers and provide distinctive examples of high-sensitivity sensors. The use of such high-sensitivity nanosensors can offer earlier detection of disease than currently available to patients and create significant improvements in clinical outcomes.

Graphical abstract: High-sensitivity nanosensors for biomarker detection

  • This article is part of the themed collection: Nanomedicine
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Publication details

The article was received on 04 Sep 2011 and first published on 20 Dec 2011


Article type: Tutorial Review
DOI: 10.1039/C1CS15238F
Chem. Soc. Rev., 2012,41, 2641-2655

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    High-sensitivity nanosensors for biomarker detection

    M. Swierczewska, G. Liu, S. Lee and X. Chen, Chem. Soc. Rev., 2012, 41, 2641
    DOI: 10.1039/C1CS15238F

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