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Issue 7, 2012
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Multifunctional nanoparticles for multimodal imaging and theragnosis

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Abstract

Nanomedicine is the biomedical application of nanoscale materials for diagnosis and therapy of disease. Recent advances in nanotechnology and biotechnology have contributed to the development of multifunctional nanoparticles as representative nanomedicine. They were initially developed to enable the target-specific delivery of imaging or therapeutic agents for biomedical applications. Due to their unique features including multifunctionality, large surface area, structural diversity, and long circulation time in blood compared to small molecules, nanoparticles have emerged as attractive preferences for optimized therapy through personalized medicine. Multimodal imaging and theragnosis are the cutting-edge technologies where the advantages of nanoparticles are maximized. Because each imaging modality has its pros and cons, the integration of several imaging agents with different properties into multifunctional nanoparticles allows precise and fast diagnosis of disease through synergetic multimodal imaging. Moreover, nanoparticles are not only used for molecular imaging but also applied to deliver therapeutic agents to the disease site in order to accomplish the simultaneous imaging and therapy called theragnosis. This tutorial review will highlight the recent advances in the development of multifunctional nanoparticles and their biomedical applications to multimodal imaging and theragnosis as nanomedicine.

Graphical abstract: Multifunctional nanoparticles for multimodal imaging and theragnosis

  • This article is part of the themed collection: Nanomedicine
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Publication details

The article was received on 22 Sep 2011 and first published on 21 Dec 2011


Article type: Tutorial Review
DOI: 10.1039/C2CS15261D
Citation: Chem. Soc. Rev., 2012,41, 2656-2672
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    Multifunctional nanoparticles for multimodal imaging and theragnosis

    D. Lee, H. Koo, I. Sun, J. H. Ryu, K. Kim and I. C. Kwon, Chem. Soc. Rev., 2012, 41, 2656
    DOI: 10.1039/C2CS15261D

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