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Issue 53, 2012
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A heme degradation enzyme, HutZ, from Vibrio cholerae

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Abstract

HutZ, one of the crucial proteins of the iron uptake system in Vibrio cholerae, was purified, which binds to heme at a stoichiometry of 1 : 1. In the presence of ascorbic acid, the HutZ-bound heme degrades via the same intermediates observed in heme oxygenase, suggesting that HutZ works as a heme degradation enzyme.

Graphical abstract: A heme degradation enzyme, HutZ, from Vibrio cholerae

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Publication details

The article was received on 15 Feb 2012, accepted on 08 May 2012 and first published on 08 May 2012


Article type: Communication
DOI: 10.1039/C2CC31147J
Chem. Commun., 2012,48, 6741-6743

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    A heme degradation enzyme, HutZ, from Vibrio cholerae

    T. Uchida, Y. Sekine, T. Matsui, M. Ikeda-Saito and K. Ishimori, Chem. Commun., 2012, 48, 6741
    DOI: 10.1039/C2CC31147J

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