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Issue 34, 2012
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Catalytic enantioselective synthesis of β-trifluoromethyl pyrrolines

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Abstract

Enantioselective synthesis of β-trifluoromethylated pyrrolines has been developed by the organocatalyzed-conjugated addition of nitromethane to β-trifluoromethylated enones, followed by a nitro-reduction/cyclization/dehydration sequence in a one-pot procedure with 97–98% ees.

Graphical abstract: Catalytic enantioselective synthesis of β-trifluoromethyl pyrrolines

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Publication details

The article was received on 23 Dec 2011, accepted on 09 Feb 2012 and first published on 10 Feb 2012


Article type: Communication
DOI: 10.1039/C2CC18049A
Chem. Commun., 2012,48, 4067-4069

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    Catalytic enantioselective synthesis of β-trifluoromethyl pyrrolines

    H. Kawai, T. Kitayama, E. Tokunaga, T. Matsumoto, H. Sato, M. Shiro and N. Shibata, Chem. Commun., 2012, 48, 4067
    DOI: 10.1039/C2CC18049A

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