Issue 34, 2012
From the journal:

Chemical Communications

Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides†

Mathew W. Jones,a   Rachel A. Strickland,a   Felix F. Schumacher,b   Stephen Caddick,b   James. R. Baker,b   Matthew I. Gibsona  and  David M. Haddleton*a  

* Corresponding authors

a Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL
E-mail: D.M.Haddleton@warwick.ac.uk
Fax: + 44 (0)24 7652 4112
Tel: + 44 (0)24 7652 3256

b Department of Chemistry, University College London, 20 Gordon Street, London, UK
E-mail: j.r.baker@ucl.ac.uk
Fax: + 44 (0)2076797463
Tel: + 44 (0)2076792653

Abstract

The direct synthesis of dithiophenol maleimide functional polymers by living radical polymerisation is described without the need for protecting group chemistry. The synthesised polymers have been successfully employed as disulfide bridging agents for salmon calcitonin when used in equimolar quantities, negating the requirement for complex purification strategies, traditionally associated with peptide bioconjugation.

Graphical abstract: Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides

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Article information

DOI
https://doi.org/10.1039/C2CC30259D
Article type
Communication
Submitted
12 Jan 2012
Accepted
28 Feb 2012
First published
29 Feb 2012

Chem. Commun., 2012,48, 4064-4066

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Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides

M. W. Jones, R. A. Strickland, F. F. Schumacher, S. Caddick, James. R. Baker, M. I. Gibson and D. M. Haddleton, Chem. Commun., 2012, 48, 4064 DOI: 10.1039/C2CC30259D

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