Jump to main content
Jump to site search

Issue 23, 2012
Previous Article Next Article

An expedient Pd/DBU mediated cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6]

Author affiliations

Abstract

A practical Pd(PPh3)4/DBU catalytic system for the synthesis of pharmaceutically relevant aminopyridine nitrile intermediates, as well as a variety of other aryl nitriles using non-toxic K4[Fe(CN)6] has been developed. The key features of our new protocol for cyanation lie in that the reaction can be carried out with readily available Pd(PPh3)4 under mild and green conditions, even without the assistance of other ligands.

Graphical abstract: An expedient Pd/DBU mediated cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6]

Back to tab navigation

Supplementary files

Article information


Submitted
30 Nov 2011
Accepted
17 Jan 2012
First published
18 Jan 2012

Chem. Commun., 2012,48, 2909-2911
Article type
Communication

An expedient Pd/DBU mediated cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6]

D. Zhang, H. Sun, L. Zhang, Y. Zhou, C. Li, H. Jiang, K. Chen and H. Liu, Chem. Commun., 2012, 48, 2909 DOI: 10.1039/C2CC17468E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements