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Issue 23, 2012
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An expedient Pd/DBU mediated cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6]

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Abstract

A practical Pd(PPh3)4/DBU catalytic system for the synthesis of pharmaceutically relevant aminopyridine nitrile intermediates, as well as a variety of other aryl nitriles using non-toxic K4[Fe(CN)6] has been developed. The key features of our new protocol for cyanation lie in that the reaction can be carried out with readily available Pd(PPh3)4 under mild and green conditions, even without the assistance of other ligands.

Graphical abstract: An expedient Pd/DBU mediated cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6]

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Publication details

The article was received on 30 Nov 2011, accepted on 17 Jan 2012 and first published on 18 Jan 2012


Article type: Communication
DOI: 10.1039/C2CC17468E
Chem. Commun., 2012,48, 2909-2911

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    An expedient Pd/DBU mediated cyanation of aryl/heteroaryl bromides with K4[Fe(CN)6]

    D. Zhang, H. Sun, L. Zhang, Y. Zhou, C. Li, H. Jiang, K. Chen and H. Liu, Chem. Commun., 2012, 48, 2909
    DOI: 10.1039/C2CC17468E

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